藥物交互作用
Concizumab + Factor viii
嚴重程度: 嚴重
Concizumab and Factor viii: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Concizumab reduces bleeding by inhibiting tissue factor pathway inhibitor, so added factor VIII at high or frequent doses can increase thrombotic risk. Thromboembolic events have been reported with concomitant breakthrough-bleed treatment.
用白話說明這項交互作用的意義
Concizumab and Factor viii can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Concizumab belongs to Miscellaneous; Factor viii belongs to Cardiovascular.
為什麼會發生
Additive procoagulant effects of TFPI inhibition and exogenous factor replacement.
處置方式
Treat breakthrough bleeds with the lowest approved factor VIII dose that achieves hemostasis. Monitor for signs of thrombosis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Concizumab 的其他交互作用
Factor viii 的其他交互作用
常見問題
Can I take Concizumab with Factor viii?
MediHelp rates the interaction as major. Concizumab and Factor viii can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concizumab reduces bleeding by inhibiting tissue factor pathway inhibitor, so added factor VIII at high or frequent doses can increase thrombotic risk. Thromboembolic events have been reported with concomitant breakthrough-bleed treatment.
How serious is the interaction between Concizumab and Factor viii?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Treat breakthrough bleeds with the lowest approved factor VIII dose that achieves hemostasis. Monitor for signs of thrombosis.
What other medicines interact with Concizumab?
MediHelp also lists interactions of Concizumab with, for example, Factor ix. The full list is on the Concizumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
