藥物交互作用
Factor viii + Marstacimab
嚴重程度: 嚴重
Factor viii and Marstacimab: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Marstacimab inhibits tissue factor pathway inhibitor and raises hemostatic potential, and adding factor VIII concentrates may further increase the risk of thromboembolic events. Factor VIII used for prophylaxis should be discontinued before starting marstacimab.
用白話說明這項交互作用的意義
Factor viii and Marstacimab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Factor viii belongs to Cardiovascular; Marstacimab belongs to Cardiovascular.
為什麼會發生
Additive procoagulant pharmacodynamic effects of TFPI inhibition and exogenous factor VIII.
處置方式
Stop factor VIII prophylaxis before starting marstacimab, and use the lowest effective factor VIII dose only for breakthrough bleeds. Monitor for signs of thrombosis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Factor viii 的其他交互作用
常見問題
Can I take Factor viii with Marstacimab?
MediHelp rates the interaction as major. Factor viii and Marstacimab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Marstacimab inhibits tissue factor pathway inhibitor and raises hemostatic potential, and adding factor VIII concentrates may further increase the risk of thromboembolic events. Factor VIII used for prophylaxis should be discontinued before starting marstacimab.
How serious is the interaction between Factor viii and Marstacimab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop factor VIII prophylaxis before starting marstacimab, and use the lowest effective factor VIII dose only for breakthrough bleeds. Monitor for signs of thrombosis.
What other medicines interact with Factor viii?
MediHelp also lists interactions of Factor viii with, for example, Concizumab. The full list is on the Factor viii page.
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