藥物交互作用
Cyclosporine + Red yeast rice
嚴重程度: 嚴重
Cyclosporine and Red yeast rice: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Monacolin K in red yeast rice is lovastatin, and cyclosporine markedly raises lovastatin exposure through CYP3A4 and OATP1B1 inhibition. This increases the risk of myopathy and rhabdomyolysis, particularly in transplant recipients.
用白話說明這項交互作用的意義
Cyclosporine and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cyclosporine inhibits CYP3A4 and hepatic OATP uptake, increasing monacolin K (lovastatin) exposure.
處置方式
Avoid red yeast rice in patients on cyclosporine and treat dyslipidemia with a statin and dose appropriate for use with cyclosporine. Monitor for muscle symptoms and creatine kinase.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Red yeast rice 的其他交互作用
常見問題
Can I take Cyclosporine with Red yeast rice?
MediHelp rates the interaction as major. Cyclosporine and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Monacolin K in red yeast rice is lovastatin, and cyclosporine markedly raises lovastatin exposure through CYP3A4 and OATP1B1 inhibition. This increases the risk of myopathy and rhabdomyolysis, particularly in transplant recipients.
How serious is the interaction between Cyclosporine and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients on cyclosporine and treat dyslipidemia with a statin and dose appropriate for use with cyclosporine. Monitor for muscle symptoms and creatine kinase.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
