藥物交互作用
Red yeast rice + Saquinavir
嚴重程度: 禁忌併用
Red yeast rice and Saquinavir: contraindicated interaction.
最後更新
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摘要
Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
用白話說明這項交互作用的意義
Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Saquinavir (with ritonavir boosting) inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
處置方式
Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Red yeast rice 的其他交互作用
常見問題
Can I take Red yeast rice with Saquinavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
How serious is the interaction between Red yeast rice and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
