藥物交互作用
Dapagliflozin-metformin + Ethiodized oil
嚴重程度: 嚴重
Dapagliflozin-metformin and Ethiodized oil: major interaction.
最後更新
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摘要
Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
用白話說明這項交互作用的意義
Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
處置方式
Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dapagliflozin-metformin 的其他交互作用
常見問題
Can I take Dapagliflozin-metformin with Ethiodized oil?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Ethiodized oil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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