藥物交互作用
Dextroamphetamine + Rasagiline
嚴重程度: 禁忌併用
Dextroamphetamine and Rasagiline: contraindicated interaction.
最後更新
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摘要
Rasagiline inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
用白話說明這項交互作用的意義
Dextroamphetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dextroamphetamine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
為什麼會發生
MAO inhibition plus indirect sympathomimetic norepinephrine release -> exaggerated pressor response
處置方式
Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dextroamphetamine 的其他交互作用
Rasagiline 的其他交互作用
常見問題
Can I take Dextroamphetamine with Rasagiline?
MediHelp rates the interaction as contraindicated. Dextroamphetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
How serious is the interaction between Dextroamphetamine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
