藥物交互作用
Diclofenac + Pemetrexed
嚴重程度: 嚴重
Diclofenac and Pemetrexed: major interaction.
最後更新
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摘要
NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
用白話說明這項交互作用的意義
Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
為什麼會發生
Reduced renal elimination of pemetrexed, likely through NSAID effects on renal perfusion and tubular handling.
處置方式
Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Diclofenac 的其他交互作用
Pemetrexed 的其他交互作用
常見問題
Can I take Diclofenac with Pemetrexed?
MediHelp rates the interaction as major. Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
How serious is the interaction between Diclofenac and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
