藥物交互作用
Dihydroergotamine intranasal + Frovatriptan
嚴重程度: 禁忌併用
Dihydroergotamine intranasal and Frovatriptan: contraindicated interaction.
最後更新
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摘要
Both drugs are vasoconstrictors acting on serotonin receptors, and together they can cause prolonged vasospasm. Cases of peripheral and cerebral ischemia are described with triptan-ergot combinations.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive vasoconstriction through 5-HT1B/1D agonism and ergot-mediated vascular receptor effects.
處置方式
Do not use within 24 hours of each other. Choose one agent for each migraine attack.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Frovatriptan 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Frovatriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are vasoconstrictors acting on serotonin receptors, and together they can cause prolonged vasospasm. Cases of peripheral and cerebral ischemia are described with triptan-ergot combinations.
How serious is the interaction between Dihydroergotamine intranasal and Frovatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other. Choose one agent for each migraine attack.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine, Eletriptan. The full list is on the Frovatriptan page.
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