藥物交互作用
Donepezil + Rivastigmine
嚴重程度: 嚴重
Donepezil and Rivastigmine: major interaction.
最後更新
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摘要
Both are cholinesterase inhibitors used for dementia, so combining them adds cholinergic toxicity without a proven benefit. Patients may develop nausea, vomiting, diarrhea, bradycardia and syncope.
用白話說明這項交互作用的意義
Donepezil and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Donepezil belongs to Central Nervous System; Rivastigmine belongs to Central Nervous System.
為什麼會發生
Duplicate acetylcholinesterase inhibition leading to additive cholinergic effects.
處置方式
Avoid concurrent use and use one cholinesterase inhibitor at a time. When switching, stop one agent and start the other at the recommended initial dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Donepezil 的其他交互作用
Rivastigmine 的其他交互作用
常見問題
Can I take Donepezil with Rivastigmine?
MediHelp rates the interaction as major. Donepezil and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are cholinesterase inhibitors used for dementia, so combining them adds cholinergic toxicity without a proven benefit. Patients may develop nausea, vomiting, diarrhea, bradycardia and syncope.
How serious is the interaction between Donepezil and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use one cholinesterase inhibitor at a time. When switching, stop one agent and start the other at the recommended initial dose.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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