藥物交互作用
Physostigmine + Rivastigmine
嚴重程度: 嚴重
Physostigmine and Rivastigmine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both drugs inhibit acetylcholinesterase, so combining them can cause cholinergic excess including bradycardia, bronchospasm, vomiting, salivation and seizures. Physostigmine crosses into the CNS and has a narrow therapeutic window.
用白話說明這項交互作用的意義
Physostigmine and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive cholinesterase inhibition.
處置方式
Avoid concurrent use unless clinically necessary, and monitor heart rate, respiration and neurological status closely. Have atropine available to treat cholinergic toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rivastigmine 的其他交互作用
常見問題
Can I take Physostigmine with Rivastigmine?
MediHelp rates the interaction as major. Physostigmine and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit acetylcholinesterase, so combining them can cause cholinergic excess including bradycardia, bronchospasm, vomiting, salivation and seizures. Physostigmine crosses into the CNS and has a narrow therapeutic window.
How serious is the interaction between Physostigmine and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless clinically necessary, and monitor heart rate, respiration and neurological status closely. Have atropine available to treat cholinergic toxicity.
What other medicines interact with Rivastigmine?
MediHelp also lists interactions of Rivastigmine with, for example, Donepezil, Galantamine, Memantine-donepezil. The full list is on the Rivastigmine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
