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Dronedarone + Nortriptyline

嚴重程度: 禁忌併用

Dronedarone and Nortriptyline: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Nortriptyline, a tricyclic antidepressant, prolongs the QTc interval and slows conduction, adding to dronedarone's effects. Dronedarone inhibits CYP2D6 and can raise nortriptyline concentrations, increasing the arrhythmia risk.

用白話說明這項交互作用的意義

Dronedarone and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dronedarone belongs to Cardiovascular; Nortriptyline belongs to Central Nervous System.

證據等級: Moderate

為什麼會發生

Additive QTc prolongation; CYP2D6 inhibition raises nortriptyline exposure

處置方式

Do not co-administer; choose an alternative that does not prolong the QT interval.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

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  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Dronedarone with Nortriptyline?

MediHelp rates the interaction as contraindicated. Dronedarone and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nortriptyline, a tricyclic antidepressant, prolongs the QTc interval and slows conduction, adding to dronedarone's effects. Dronedarone inhibits CYP2D6 and can raise nortriptyline concentrations, increasing the arrhythmia risk.

How serious is the interaction between Dronedarone and Nortriptyline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.

What other medicines interact with Dronedarone?

MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.

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