藥物交互作用

Drospirenone + Ivosidenib

嚴重程度: 嚴重

Drospirenone and Ivosidenib: major interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.

用白話說明這項交互作用的意義

Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Drospirenone belongs to Endocrine; Ivosidenib belongs to Oncology.

證據等級: Moderate

為什麼會發生

Ivosidenib induces CYP3A4, increasing the metabolism of drospirenone and lowering its concentrations.

處置方式

Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.

可向藥師詢問的問題

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Drospirenone 與 Ivosidenib 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

建立免費帳號登入

在網頁版免費試用 Pro+ 14 天，無需信用卡。

常見問題

Can I take Drospirenone with Ivosidenib?

MediHelp rates the interaction as major. Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.

How serious is the interaction between Drospirenone and Ivosidenib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.

What other medicines interact with Drospirenone?

MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.

在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查

在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。

下載於App Store 立即下載Google Play

依 A–Z 瀏覽 · 藥物交互作用

摘要