藥物交互作用
Amitriptyline + Ivosidenib
嚴重程度: 嚴重
Amitriptyline and Ivosidenib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs prolong the QT interval. Combined use increases the risk of torsades de pointes.
用白話說明這項交互作用的意義
Amitriptyline and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Ivosidenib belongs to Oncology.
為什麼會發生
Additive QT prolongation.
處置方式
Use an alternative antidepressant where possible. If both are needed, monitor ECG and electrolytes and reduce ivosidenib as labeling advises for QT prolongation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amitriptyline 的其他交互作用
Ivosidenib 的其他交互作用
常見問題
Can I take Amitriptyline with Ivosidenib?
MediHelp rates the interaction as major. Amitriptyline and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Amitriptyline and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antidepressant where possible. If both are needed, monitor ECG and electrolytes and reduce ivosidenib as labeling advises for QT prolongation.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
