藥物交互作用
Econazole + Warfarin
嚴重程度: 中度
Econazole and Warfarin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Topical econazole applied over large areas, to genital skin or under occlusive dressings can be absorbed enough to raise the INR in patients taking warfarin. Bleeding episodes have been reported with azole antifungals used this way.
用白話說明這項交互作用的意義
Econazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Econazole belongs to Anti Fungals; Warfarin belongs to Cardiovascular.
為什麼會發生
Systemically absorbed econazole inhibits CYP2C9 and other CYP enzymes, reducing clearance of the more potent S-warfarin.
處置方式
Check INR within several days of starting econazole, particularly with extensive, genital or occluded application, and adjust the warfarin dose as needed. Limit the treated area where possible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Warfarin 的其他交互作用
常見問題
Can I take Econazole with Warfarin?
MediHelp rates the interaction as moderate. Econazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical econazole applied over large areas, to genital skin or under occlusive dressings can be absorbed enough to raise the INR in patients taking warfarin. Bleeding episodes have been reported with azole antifungals used this way.
How serious is the interaction between Econazole and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within several days of starting econazole, particularly with extensive, genital or occluded application, and adjust the warfarin dose as needed. Limit the treated area where possible.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
