藥物交互作用
Elbasvir / grazoprevir + Rosuvastatin
嚴重程度: 嚴重
Elbasvir / grazoprevir and Rosuvastatin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Grazoprevir and elbasvir raise rosuvastatin exposure, notably through BCRP and OATP1B inhibition. Higher levels increase the risk of myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Elbasvir / grazoprevir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of BCRP and OATP1B transporters increases rosuvastatin plasma concentrations.
處置方式
Keep rosuvastatin at or below 10 mg daily during co-administration and monitor for muscle symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rosuvastatin 的其他交互作用
常見問題
Can I take Elbasvir / grazoprevir with Rosuvastatin?
MediHelp rates the interaction as major. Elbasvir / grazoprevir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Grazoprevir and elbasvir raise rosuvastatin exposure, notably through BCRP and OATP1B inhibition. Higher levels increase the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Elbasvir / grazoprevir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep rosuvastatin at or below 10 mg daily during co-administration and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
