藥物交互作用
Darolutamide + Rosuvastatin
嚴重程度: 嚴重
Darolutamide and Rosuvastatin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Darolutamide inhibits BCRP and increases rosuvastatin exposure. Higher levels raise the risk of muscle toxicity.
用白話說明這項交互作用的意義
Darolutamide and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darolutamide belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
為什麼會發生
Darolutamide inhibits BCRP-mediated intestinal efflux of rosuvastatin.
處置方式
Avoid if possible; otherwise limit rosuvastatin to 5 mg daily and monitor for muscle symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rosuvastatin 的其他交互作用
Darolutamide 的其他交互作用
常見問題
Can I take Darolutamide with Rosuvastatin?
MediHelp rates the interaction as major. Darolutamide and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darolutamide inhibits BCRP and increases rosuvastatin exposure. Higher levels raise the risk of muscle toxicity.
How serious is the interaction between Darolutamide and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise limit rosuvastatin to 5 mg daily and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
