藥物交互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone
嚴重程度: 禁忌併用
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eplerenone: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
The cobicistat component strongly inhibits CYP3A4 and raises eplerenone levels. This increases the risk of serious hyperkalemia.
用白話說明這項交互作用的意義
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cobicistat inhibits CYP3A4-mediated eplerenone metabolism.
處置方式
Avoid concurrent use; choose an alternative antihypertensive or heart failure therapy, or a non-boosted antiretroviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eplerenone 的其他交互作用
常見問題
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Eplerenone?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component strongly inhibits CYP3A4 and raises eplerenone levels. This increases the risk of serious hyperkalemia.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eplerenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative antihypertensive or heart failure therapy, or a non-boosted antiretroviral regimen.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
