藥物交互作用
Cobicistat + Eplerenone
嚴重程度: 禁忌併用
Cobicistat and Eplerenone: contraindicated interaction.
最後更新
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摘要
Cobicistat is a strong CYP3A4 inhibitor and markedly raises eplerenone exposure. This increases the risk of severe hyperkalemia with potentially dangerous cardiac arrhythmias.
用白話說明這項交互作用的意義
Cobicistat and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Eplerenone belongs to Cardiovascular.
為什麼會發生
Strong inhibition of CYP3A4-mediated eplerenone metabolism.
處置方式
Do not use together; choose an alternative antihypertensive or heart failure agent, or an alternative antiretroviral booster regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eplerenone 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Eplerenone?
MediHelp rates the interaction as contraindicated. Cobicistat and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises eplerenone exposure. This increases the risk of severe hyperkalemia with potentially dangerous cardiac arrhythmias.
How serious is the interaction between Cobicistat and Eplerenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative antihypertensive or heart failure agent, or an alternative antiretroviral booster regimen.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
