藥物交互作用
Erlotinib + Vonoprazan
嚴重程度: 嚴重
Erlotinib and Vonoprazan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Erlotinib absorption depends on an acidic gastric pH, and vonoprazan produces potent, lasting acid suppression. Erlotinib exposure may fall substantially, reducing efficacy.
用白話說明這項交互作用的意義
Erlotinib and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Vonoprazan belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH from vonoprazan reduces the solubility and absorption of erlotinib.
處置方式
Avoid vonoprazan and other potent acid suppressants where possible. If acid suppression is essential, monitor for reduced response to erlotinib.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Erlotinib 的其他交互作用
Vonoprazan 的其他交互作用
常見問題
Can I take Erlotinib with Vonoprazan?
MediHelp rates the interaction as major. Erlotinib and Vonoprazan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erlotinib absorption depends on an acidic gastric pH, and vonoprazan produces potent, lasting acid suppression. Erlotinib exposure may fall substantially, reducing efficacy.
How serious is the interaction between Erlotinib and Vonoprazan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vonoprazan and other potent acid suppressants where possible. If acid suppression is essential, monitor for reduced response to erlotinib.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
