藥品參考
Vonoprazan
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for gerd.
- 藥物類別: Gastrointestinal Tract
- 用途: gerd
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Gastrointestinal Tract
- 常見劑型
- 錠劑
- 常見規格
- 20 mg, 10 mg
- 已知交互作用
- 42 (嚴重: 6 · 中度: 26 · 輕微: 10)
- 商品名
- 10
- 國家與市場
- 2
用途
作用方式
Vonoprazan suppresses basal and stimulated gastric acid secretion by inhibiting the H+,K+-ATPase enzyme system in parietal cells in a potassium-competitive manner. It binds to active pumps noncovalently and reversibly and does not require activation by acid.
成人常用劑量（仿單摘要）
Healing of erosive esophagitis: 20 mg orally once daily for 8 weeks
一般服用方式
Proton pump inhibitors are usually taken by mouth once a day, often before a meal, for a course whose length depends on the reason for treatment.
懷孕與哺乳
- 懷孕
- Unknown No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists.
- 哺乳
- Unknown Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
已通報的副作用
- Gastritis
- Diarrhea
- Abdominal pain
- Nausea
- Abdominal distension
- Dyspepsia
禁忌症
- Known hypersensitivity to vonoprazan or any component of the product (reactions have included anaphylactic shock)
- Concomitant use with rilpivirine-containing products
哪些人需要特別留意
- Symptomatic response does not preclude gastric malignancy; consider further follow-up and testing, and endoscopy in older patients.
- Acute tubulointerstitial nephritis: discontinue and evaluate if suspected.
- May increase risk of Clostridioides difficile-associated diarrhea; use the shortest duration appropriate.
People taking proton pump inhibitors for a long time should have the need for treatment reviewed, because long-term use is linked to low magnesium, vitamin B12 deficiency, bone fractures and gut infections. Tell your pharmacist about all other medicines, since some interact.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (42)
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
- Armodafinil + Vonoprazan Moderate
- Bosentan + Vonoprazan Moderate
- Carbonyl iron + Vonoprazan Moderate
- Cilostazol + Vonoprazan Moderate
同類別的其他藥品
常見問題
What is Vonoprazan used for?
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for GERD, Heartburn, Helicobacter pylori bacteria.
What side effects have been reported with Vonoprazan?
Gastritis, Diarrhea, Abdominal pain, Nausea, Abdominal distension, Dyspepsia.
Can Vonoprazan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists. Breastfeeding: Unknown. Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
What does Vonoprazan interact with?
MediHelp lists 42 known interactions for Vonoprazan. Major: 6 · Moderate: 26 · Minor: 10. The most serious include Amobarbital, Apalutamide, Atazanavir.
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