藥物交互作用
Ethanol + Oxymorphone
嚴重程度: 禁忌併用
Ethanol and Oxymorphone: contraindicated interaction.
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摘要
Alcohol taken with oxymorphone increases sedation and respiratory depression and can be fatal. With the extended-release oxymorphone formulation, alcohol can also cause rapid release of the whole dose (dose dumping), leading to a potentially lethal overdose.
用白話說明這項交互作用的意義
Ethanol and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive CNS depression, plus alcohol-induced disruption of the extended-release formulation that raises peak oxymorphone exposure.
處置方式
Instruct patients to avoid alcohol and any alcohol-containing medicines during oxymorphone therapy. Extended-release oxymorphone is contraindicated with alcohol.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Oxymorphone 的其他交互作用
常見問題
Can I take Ethanol with Oxymorphone?
MediHelp rates the interaction as contraindicated. Ethanol and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alcohol taken with oxymorphone increases sedation and respiratory depression and can be fatal. With the extended-release oxymorphone formulation, alcohol can also cause rapid release of the whole dose (dose dumping), leading to a potentially lethal overdose.
How serious is the interaction between Ethanol and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Instruct patients to avoid alcohol and any alcohol-containing medicines during oxymorphone therapy. Extended-release oxymorphone is contraindicated with alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Oxymorphone page.
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