藥物交互作用
Isocarboxazid + Oxymorphone
嚴重程度: 禁忌併用
Isocarboxazid and Oxymorphone: contraindicated interaction.
最後更新
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摘要
Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.
用白話說明這項交互作用的意義
Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
為什麼會發生
MAO inhibition potentiates opioid CNS effects and may cause serotonergic or autonomic toxicity; the exact mechanism varies by opioid.
處置方式
Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Oxymorphone 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Isocarboxazid with Oxymorphone?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Isocarboxazid and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Olanzapine / samidorphan. The full list is on the Oxymorphone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
