藥物交互作用
Famotidine + Itraconazole
嚴重程度: 嚴重
Famotidine and Itraconazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Itraconazole capsules need gastric acid for absorption, and famotidine can markedly reduce their bioavailability. Subtherapeutic levels can cause antifungal failure.
用白話說明這項交互作用的意義
Famotidine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Famotidine belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
為什麼會發生
Reduced acid-dependent dissolution and absorption of itraconazole capsules.
處置方式
Avoid with capsules, or use the oral solution or SUBA-itraconazole. Monitor itraconazole levels and clinical response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Famotidine 的其他交互作用
Itraconazole 的其他交互作用
常見問題
Can I take Famotidine with Itraconazole?
MediHelp rates the interaction as major. Famotidine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole capsules need gastric acid for absorption, and famotidine can markedly reduce their bioavailability. Subtherapeutic levels can cause antifungal failure.
How serious is the interaction between Famotidine and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with capsules, or use the oral solution or SUBA-itraconazole. Monitor itraconazole levels and clinical response.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
