藥物交互作用
Fluvoxamine + Phenelzine
嚴重程度: 禁忌併用
Fluvoxamine and Phenelzine: contraindicated interaction.
最後更新
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摘要
Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
用白話說明這項交互作用的意義
Fluvoxamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
為什麼會發生
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
處置方式
Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting phenelzine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluvoxamine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Fluvoxamine with Phenelzine?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Fluvoxamine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting phenelzine.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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