藥物交互作用
Ganciclovir + Imipenem / cilastatin
嚴重程度: 嚴重
Ganciclovir and Imipenem / cilastatin: major interaction.
最後更新
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摘要
Generalized seizures have been reported in patients given ganciclovir together with imipenem/cilastatin. Imipenem can lower the seizure threshold, and the combination appears to add to that risk.
用白話說明這項交互作用的意義
Ganciclovir and Imipenem / cilastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Probable additive lowering of the seizure threshold; the exact mechanism is not established.
處置方式
Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If it must be used, adjust doses for renal function and monitor for neurological symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ganciclovir 的其他交互作用
常見問題
Can I take Ganciclovir with Imipenem / cilastatin?
MediHelp rates the interaction as major. Ganciclovir and Imipenem / cilastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Generalized seizures have been reported in patients given ganciclovir together with imipenem/cilastatin. Imipenem can lower the seizure threshold, and the combination appears to add to that risk.
How serious is the interaction between Ganciclovir and Imipenem / cilastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If it must be used, adjust doses for renal function and monitor for neurological symptoms.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
