藥物交互作用
Glimepiride-pioglitazone + Sulfamethoxazole
嚴重程度: 嚴重
Glimepiride-pioglitazone and Sulfamethoxazole: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
用白話說明這項交互作用的意義
Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Sulfamethoxazole inhibits CYP2C9 metabolism of sulfonylureas and may displace them from protein binding, increasing glimepiride exposure.
處置方式
Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glimepiride-pioglitazone 的其他交互作用
常見問題
Can I take Glimepiride-pioglitazone with Sulfamethoxazole?
MediHelp rates the interaction as major. Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
