藥物交互作用
Glimepiride-pioglitazone + Insulin aspart
嚴重程度: 嚴重
Glimepiride-pioglitazone and Insulin aspart: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining insulin with glimepiride and pioglitazone increases the risk of hypoglycemia. Insulin with pioglitazone also raises the risk of fluid retention, edema and heart failure.
用白話說明這項交互作用的意義
Glimepiride-pioglitazone and Insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glimepiride-pioglitazone belongs to Endocrine; Insulin aspart belongs to Endocrine.
為什麼會發生
Additive glucose lowering, and thiazolidinedione-induced sodium and fluid retention is amplified by insulin.
處置方式
Reduce insulin or sulfonylurea doses as needed and monitor glucose. Watch for weight gain, edema and heart failure symptoms, particularly in patients with cardiac risk.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glimepiride-pioglitazone 的其他交互作用
Insulin aspart 的其他交互作用
常見問題
Can I take Glimepiride-pioglitazone with Insulin aspart?
MediHelp rates the interaction as major. Glimepiride-pioglitazone and Insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining insulin with glimepiride and pioglitazone increases the risk of hypoglycemia. Insulin with pioglitazone also raises the risk of fluid retention, edema and heart failure.
How serious is the interaction between Glimepiride-pioglitazone and Insulin aspart?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce insulin or sulfonylurea doses as needed and monitor glucose. Watch for weight gain, edema and heart failure symptoms, particularly in patients with cardiac risk.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin degludec. The full list is on the Glimepiride-pioglitazone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
