藥物交互作用
Insulin aspart + Metformin-pioglitazone
嚴重程度: 嚴重
Insulin aspart and Metformin-pioglitazone: major interaction.
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摘要
Pioglitazone combined with insulin increases the risk of fluid retention, edema and heart failure, and glucose-lowering effects are additive so hypoglycemia can occur. Metformin adds to the glucose-lowering effect.
用白話說明這項交互作用的意義
Insulin aspart and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin aspart belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
為什麼會發生
Additive glucose lowering, with insulin and PPAR-gamma agonism both promoting sodium and fluid retention.
處置方式
Monitor weight, edema and signs of heart failure, and reduce the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin-pioglitazone 的其他交互作用
Insulin aspart 的其他交互作用
常見問題
Can I take Insulin aspart with Metformin-pioglitazone?
MediHelp rates the interaction as major. Insulin aspart and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pioglitazone combined with insulin increases the risk of fluid retention, edema and heart failure, and glucose-lowering effects are additive so hypoglycemia can occur. Metformin adds to the glucose-lowering effect.
How serious is the interaction between Insulin aspart and Metformin-pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and signs of heart failure, and reduce the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
