藥物交互作用
Itraconazole + Pralsetinib
嚴重程度: 嚴重
Itraconazole and Pralsetinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Itraconazole raises pralsetinib exposure by inhibiting its metabolism. This may increase risks of pneumonitis, hepatotoxicity, hypertension and hemorrhage.
用白話說明這項交互作用的意義
Itraconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Pralsetinib belongs to Oncology.
為什麼會發生
Strong CYP3A4 and P-glycoprotein inhibition reduces pralsetinib clearance.
處置方式
Avoid if possible. If unavoidable, reduce the pralsetinib dose per labeling and monitor liver function and for toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Itraconazole 的其他交互作用
Pralsetinib 的其他交互作用
常見問題
Can I take Itraconazole with Pralsetinib?
MediHelp rates the interaction as major. Itraconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises pralsetinib exposure by inhibiting its metabolism. This may increase risks of pneumonitis, hepatotoxicity, hypertension and hemorrhage.
How serious is the interaction between Itraconazole and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the pralsetinib dose per labeling and monitor liver function and for toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
