藥物交互作用
Efavirenz + Pralsetinib
嚴重程度: 嚴重
Efavirenz and Pralsetinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Efavirenz may reduce pralsetinib concentrations and weaken its effect against RET-driven cancers.
用白話說明這項交互作用的意義
Efavirenz and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Pralsetinib belongs to Oncology.
為什麼會發生
CYP3A4 induction by efavirenz increases pralsetinib clearance.
處置方式
Avoid if possible and use a non-inducing antiretroviral. If unavoidable, follow labeled dose-increase guidance and monitor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Efavirenz 的其他交互作用
Pralsetinib 的其他交互作用
常見問題
Can I take Efavirenz with Pralsetinib?
MediHelp rates the interaction as major. Efavirenz and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may reduce pralsetinib concentrations and weaken its effect against RET-driven cancers.
How serious is the interaction between Efavirenz and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-inducing antiretroviral. If unavoidable, follow labeled dose-increase guidance and monitor response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
