藥物交互作用
Lapatinib + Selexipag
嚴重程度: 中度
Lapatinib and Selexipag: moderate interaction.
最後更新
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摘要
Lapatinib may inhibit CYP2C8 and BCRP, raising exposure to selexipag and its active metabolite. This may increase headache, flushing, nausea, diarrhea and hypotension.
用白話說明這項交互作用的意義
Lapatinib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Selexipag belongs to Cardiovascular.
為什麼會發生
Inhibition of CYP2C8 metabolism and BCRP transport by lapatinib.
處置方式
Monitor for prostacyclin-related adverse effects and blood pressure, and reduce selexipag frequency if poorly tolerated.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Lapatinib 的其他交互作用
Selexipag 的其他交互作用
常見問題
Can I take Lapatinib with Selexipag?
MediHelp rates the interaction as moderate. Lapatinib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may inhibit CYP2C8 and BCRP, raising exposure to selexipag and its active metabolite. This may increase headache, flushing, nausea, diarrhea and hypotension.
How serious is the interaction between Lapatinib and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and blood pressure, and reduce selexipag frequency if poorly tolerated.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
