藥品參考
Selexipag
Selexipag is a medicine in the class cardiovascular. It is used for pulmonary hypertension.
- 藥物類別: Cardiovascular
- 用途: pulmonary hypertension
最後更新 來源: US FDA label, EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Cardiovascular
- ATC 代碼
- B01AC27
- 常見劑型
- 錠劑, 注射劑
- 常見規格
- 1000 mcg
- 已知交互作用
- 36 (禁忌併用: 1 · 中度: 20 · 輕微: 15)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Selexipag is a prostacyclin (IP) receptor agonist, structurally distinct from prostacyclin. It is hydrolyzed by carboxylesterase 1 to an active metabolite that is approximately 37-fold as potent as selexipag.
成人常用劑量（仿單摘要）
PAH (tablets): start 200 mcg orally twice daily; increase by 200 mcg twice daily, usually at weekly intervals, to the highest tolerated dose up to 1,600 mcg twice daily; if a dose is not tolerated, reduce to the previous tolerated dose
懷孕與哺乳
- 懷孕
- Unknown No adequate and well-controlled studies in pregnant women. Animal studies showed no clinically relevant effects on embryofetal development.
- 哺乳
- Unsafe Not known whether present in human milk; present in rat milk. Discontinue nursing or discontinue UPTRAVI.
已通報的副作用
- Headache
- Diarrhea
- Nausea
- Jaw pain
- Vomiting
- Pain in extremity
禁忌症
- Hypersensitivity to the active substance or any excipients
- Concomitant use of strong CYP2C8 inhibitors (e.g., gemfibrozil)
哪些人需要特別留意
- Pulmonary edema may signal pulmonary veno-occlusive disease; if confirmed, discontinue.
- Pediatric patients had smaller mean increases in weight and height than placebo; monitor growth.
- Hyperthyroidism was observed in 1% of adults on tablets and in none on placebo.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (36)
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
- Deferasirox + Selexipag Moderate
- Eltrombopag + Selexipag Moderate
- Lapatinib + Selexipag Moderate
- Losartan + Selexipag Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Selexipag 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 7 天，無需信用卡。
常見問題
What is Selexipag used for?
Selexipag is a medicine in the class cardiovascular. It is used for Pulmonary hypertension.
What side effects have been reported with Selexipag?
Headache, Diarrhea, Nausea, Jaw pain, Vomiting, Pain in extremity.
Can Selexipag be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate and well-controlled studies in pregnant women. Animal studies showed no clinically relevant effects on embryofetal development. Breastfeeding: Unsafe. Not known whether present in human milk; present in rat milk. Discontinue nursing or discontinue UPTRAVI.
What does Selexipag interact with?
MediHelp lists 36 known interactions for Selexipag. Contraindicated: 1 · Moderate: 20 · Minor: 15. The most serious include Gemfibrozil, Abiraterone, Apalutamide.
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