藥物交互作用
Lithium + Thioridazine
嚴重程度: 禁忌併用
Lithium and Thioridazine: contraindicated interaction.
最後更新
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摘要
Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
用白話說明這項交互作用的意義
Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lithium belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation, with possible pharmacodynamic neurotoxic synergy.
處置方式
Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lithium 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Lithium with Thioridazine?
MediHelp rates the interaction as contraindicated. Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
How serious is the interaction between Lithium and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Vandetanib, Aceclofenac, Acemetacin. The full list is on the Lithium page.
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