藥物交互作用
Lithium + Vandetanib
嚴重程度: 禁忌併用
Lithium and Vandetanib: contraindicated interaction.
最後更新
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摘要
Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and lithium may add to this risk. Concurrent QT-prolonging drugs are to be avoided.
用白話說明這項交互作用的意義
Lithium and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lithium belongs to Central Nervous System; Vandetanib belongs to Oncology.
為什麼會發生
Additive QTc prolongation; vandetanib is a potent QT-prolonging agent with a long half-life.
處置方式
Avoid the combination and use an alternative to lithium. If both are unavoidable, monitor ECG and electrolytes frequently.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lithium 的其他交互作用
Vandetanib 的其他交互作用
常見問題
Can I take Lithium with Vandetanib?
MediHelp rates the interaction as contraindicated. Lithium and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and lithium may add to this risk. Concurrent QT-prolonging drugs are to be avoided.
How serious is the interaction between Lithium and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative to lithium. If both are unavoidable, monitor ECG and electrolytes frequently.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Aceclofenac, Acemetacin. The full list is on the Lithium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
