藥物交互作用
Magnesium sulfate + Vecuronium
嚴重程度: 嚴重
Magnesium sulfate and Vecuronium: major interaction.
最後更新
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摘要
Parenteral magnesium sulfate potentiates non-depolarizing neuromuscular blockers, giving a faster onset, deeper block and longer recovery. This can lead to prolonged paralysis and respiratory depression.
用白話說明這項交互作用的意義
Magnesium sulfate and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity, adding to competitive blockade by vecuronium.
處置方式
Reduce the vecuronium dose and titrate with quantitative train-of-four monitoring in patients receiving magnesium. Be prepared for delayed recovery and ventilatory support, and check serum magnesium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vecuronium 的其他交互作用
常見問題
Can I take Magnesium sulfate with Vecuronium?
MediHelp rates the interaction as major. Magnesium sulfate and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral magnesium sulfate potentiates non-depolarizing neuromuscular blockers, giving a faster onset, deeper block and longer recovery. This can lead to prolonged paralysis and respiratory depression.
How serious is the interaction between Magnesium sulfate and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vecuronium dose and titrate with quantitative train-of-four monitoring in patients receiving magnesium. Be prepared for delayed recovery and ventilatory support, and check serum magnesium.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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