藥物交互作用
Measles mumps and rubella vaccine + Methotrexate
嚴重程度: 禁忌併用
Measles mumps and rubella vaccine and Methotrexate: contraindicated interaction.
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摘要
Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
用白話說明這項交互作用的意義
Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Methotrexate belongs to Oncology.
為什麼會發生
Antimetabolite-induced immunosuppression impairs the immune response to live attenuated virus and permits vaccine virus replication.
處置方式
Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Measles mumps and rubella vaccine 的其他交互作用
- Adalimumab + Measles mumps and rubella vaccine 禁忌併用
- Anakinra + Measles mumps and rubella vaccine 禁忌併用
- Antithymocyte globulin equine + Measles mumps and rubella vaccine 禁忌併用
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine 禁忌併用
- Azathioprine + Measles mumps and rubella vaccine 禁忌併用
- Basiliximab + Measles mumps and rubella vaccine 禁忌併用
Methotrexate 的其他交互作用
- Acitretin + Methotrexate 禁忌併用
- Adenovirus types 4 and 7 live + Methotrexate 禁忌併用
- Influenza virus vaccine quadrivalent intranasal + Methotrexate 禁忌併用
- Ketorolac + Methotrexate 禁忌併用
- Measles mumps and rubella vaccine live + Methotrexate 禁忌併用
- Measles mumps rubella and varicella vaccine live + Methotrexate 禁忌併用
常見問題
Can I take Measles mumps and rubella vaccine with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
How serious is the interaction between Measles mumps and rubella vaccine and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
