藥物交互作用
Measles mumps and rubella vaccine live + Methotrexate
嚴重程度: 禁忌併用
Measles mumps and rubella vaccine live and Methotrexate: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.
用白話說明這項交互作用的意義
Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Methotrexate suppresses lymphocyte proliferation, allowing replication of live attenuated viruses.
處置方式
Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Methotrexate 的其他交互作用
常見問題
Can I take Measles mumps and rubella vaccine live with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.
How serious is the interaction between Measles mumps and rubella vaccine live and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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