藥物交互作用
Measles mumps and rubella vaccine live + Melphalan
嚴重程度: 禁忌併用
Measles mumps and rubella vaccine live and Melphalan: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
用白話說明這項交互作用的意義
Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
處置方式
Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Melphalan 的其他交互作用
常見問題
Can I take Measles mumps and rubella vaccine live with Melphalan?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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