藥物交互作用
Methylene blue + Venlafaxine
嚴重程度: 禁忌併用
Methylene blue and Venlafaxine: contraindicated interaction.
最後更新
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摘要
Methylene blue is a potent MAO-A inhibitor and, combined with serotonin reuptake inhibitors like venlafaxine, can cause severe serotonin syndrome. Reactions have occurred with intravenous methylene blue given for methemoglobinemia or during surgery.
用白話說明這項交互作用的意義
Methylene blue and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO-A inhibition by methylene blue added to serotonin reuptake inhibition.
處置方式
Avoid unless methylene blue is needed for an emergency; then stop venlafaxine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Venlafaxine 的其他交互作用
常見問題
Can I take Methylene blue with Venlafaxine?
MediHelp rates the interaction as contraindicated. Methylene blue and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue is a potent MAO-A inhibitor and, combined with serotonin reuptake inhibitors like venlafaxine, can cause severe serotonin syndrome. Reactions have occurred with intravenous methylene blue given for methemoglobinemia or during surgery.
How serious is the interaction between Methylene blue and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; then stop venlafaxine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Venlafaxine page.
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