藥物交互作用
Phenelzine + Venlafaxine
嚴重程度: 禁忌併用
Phenelzine and Venlafaxine: contraindicated interaction.
最後更新
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摘要
Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.
用白話說明這項交互作用的意義
Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
為什麼會發生
Serotonin and noradrenaline reuptake inhibition combined with irreversible MAO inhibition causes monoamine excess.
處置方式
Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Venlafaxine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Phenelzine with Venlafaxine?
MediHelp rates the interaction as contraindicated. Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.
How serious is the interaction between Phenelzine and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Procarbazine. The full list is on the Venlafaxine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
