藥物交互作用
Pentamidine + Ziprasidone
嚴重程度: 禁忌併用
Pentamidine and Ziprasidone: contraindicated interaction.
最後更新
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摘要
Systemic pentamidine can prolong the QT interval and has been linked to torsades de pointes, and ziprasidone has similar effects. Using both increases the risk of serious ventricular arrhythmias. Pentamidine can also cause electrolyte disturbances that worsen this risk.
用白話說明這項交互作用的意義
Pentamidine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pentamidine belongs to Anti Parasitic; Ziprasidone belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation through cardiac repolarization delay, with pentamidine-related hypokalemia or hypomagnesemia as a contributor.
處置方式
Avoid concurrent use; hold ziprasidone or choose another anti-infective if possible. If unavoidable, correct electrolytes beforehand and monitor ECG continuously.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ziprasidone 的其他交互作用
Pentamidine 的其他交互作用
常見問題
Can I take Pentamidine with Ziprasidone?
MediHelp rates the interaction as contraindicated. Pentamidine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Systemic pentamidine can prolong the QT interval and has been linked to torsades de pointes, and ziprasidone has similar effects. Using both increases the risk of serious ventricular arrhythmias. Pentamidine can also cause electrolyte disturbances that worsen this risk.
How serious is the interaction between Pentamidine and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold ziprasidone or choose another anti-infective if possible. If unavoidable, correct electrolytes beforehand and monitor ECG continuously.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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