藥物交互作用
Phenindione + Vitamin e
嚴重程度: 中度
Phenindione and Vitamin e: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Phenindione is an oral vitamin K antagonist, and high doses of vitamin E may further impair vitamin K-dependent clotting and platelet function. This may increase bleeding risk, mainly with megadoses.
用白話說明這項交互作用的意義
Phenindione and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
High-dose vitamin E antagonizes vitamin K-dependent clotting factor synthesis and inhibits platelet aggregation, adding to phenindione's effect.
處置方式
Avoid vitamin E megadoses in patients on phenindione. Monitor INR and bleeding signs if supplementation is started or stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Vitamin e 的其他交互作用
常見問題
Can I take Phenindione with Vitamin e?
MediHelp rates the interaction as moderate. Phenindione and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenindione is an oral vitamin K antagonist, and high doses of vitamin E may further impair vitamin K-dependent clotting and platelet function. This may increase bleeding risk, mainly with megadoses.
How serious is the interaction between Phenindione and Vitamin e?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin E megadoses in patients on phenindione. Monitor INR and bleeding signs if supplementation is started or stopped.
What other medicines interact with Vitamin e?
MediHelp also lists interactions of Vitamin e with, for example, Betrixaban, Selumetinib, Warfarin. The full list is on the Vitamin e page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
