藥物交互作用
Propranolol + Thioridazine
嚴重程度: 禁忌併用
Propranolol and Thioridazine: contraindicated interaction.
最後更新
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摘要
Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
用白話說明這項交互作用的意義
Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Propranolol belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
為什麼會發生
Mutual metabolic inhibition involving CYP2D6, with additive cardiac depressant and proarrhythmic effects.
處置方式
Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Propranolol 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Propranolol with Thioridazine?
MediHelp rates the interaction as contraindicated. Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
How serious is the interaction between Propranolol and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Propranolol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
