藥物交互作用
Tigecycline + Typhoid vaccine live
嚴重程度: 嚴重
Tigecycline and Typhoid vaccine live: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
用白話說明這項交互作用的意義
Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Antibacterial activity kills or inhibits the live attenuated Salmonella strain, reducing colonisation and immunogenicity.
處置方式
Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tigecycline 的其他交互作用
常見問題
Can I take Tigecycline with Typhoid vaccine live?
MediHelp rates the interaction as major. Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
How serious is the interaction between Tigecycline and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Bcg vaccine live, Cholera vaccine, Microbiota. The full list is on the Tigecycline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
