Drug interactions
Tigecycline + Typhoid vaccine live
Severity: Major
Tigecycline and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
What this interaction means in plain words
Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity kills or inhibits the live attenuated Salmonella strain, reducing colonisation and immunogenicity.
What to do
Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tigecycline
Frequently asked questions
Can I take Tigecycline with Typhoid vaccine live?
MediHelp rates the interaction as major. Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
How serious is the interaction between Tigecycline and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Bcg vaccine live, Cholera vaccine, Microbiota. The full list is on the Tigecycline page.
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