Drug reference
alendronate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (Bisphosphonate)
Mechanism of action
Bisphosphonate; binds to hydroxyapatite crystals in bone and inhibits osteoclast-mediated bone resorption; decreases mineral release and collagen or matrix breakdown in bone
Common side effects
- Flatulence
- Dyspepsia
- Headache
- Muscle or joint pain
- Acid regurgitation
- Esophageal ulcer
- Abdominal pain
Contraindications
- Hypersensitivity Hypocalcemia Abnormalities of the esophagus delaying esophageal emptying such as stricture or achalasia Inability to stand or sit upright for 30 minutes
Known interactions (1)
- alendronate + aspirin Moderate
Related conditions
Frequently asked questions
What drug class is alendronate?
alendronate belongs to: Musculoskeletal.
How does alendronate work?
Bisphosphonate; binds to hydroxyapatite crystals in bone and inhibits osteoclast-mediated bone resorption; decreases mineral release and collagen or matrix breakdown in bone
What are the common side effects of alendronate?
Flatulence, Dyspepsia, Headache, Muscle or joint pain, Acid regurgitation, Esophageal ulcer, Abdominal pain
Which drugs interact with alendronate?
aspirin
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