Drug reference
aprepitant
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Miscellaneous(GIT))
Mechanism of action
Selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors; aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors.
Common side effects
- Malaise/fatigue
- Constipation
- Headache
- Hypoxia
Contraindications
- Hypersensitivity Concomitant pimozide
Known interactions (15)
- aprepitant + pimozide Contraindicated
- aprepitant + colchicine Major
- aprepitant + dronedarone Major
- aprepitant + ergotamine Major
- aprepitant + everolimus Major
- aprepitant + flibanserin Major
- aprepitant + lovastatin Major
- aprepitant + simvastatin Major
- aprepitant + tolvaptan Major
- aprepitant + chloramphenicol Moderate
- aprepitant + erythromycin Moderate
- aprepitant + ranolazine Moderate
- aprepitant + ribociclib Moderate
- aprepitant + silodosin Moderate
- aprepitant + sirolimus Moderate
Related conditions
Frequently asked questions
What drug class is aprepitant?
aprepitant belongs to: Gastrointestinal Tract.
How does aprepitant work?
Selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors; aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors.
What are the common side effects of aprepitant?
Malaise/fatigue, Constipation, Headache, Hypoxia
Which drugs interact with aprepitant?
pimozide, colchicine, dronedarone, ergotamine, everolimus, flibanserin, lovastatin, simvastatin, tolvaptan, chloramphenicol, erythromycin, ranolazine, ribociclib, silodosin, sirolimus
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