Drug interactions
Aprepitant + Carbamazepine
Severity: Major
Aprepitant and Carbamazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and can markedly reduce aprepitant levels, risking loss of antiemetic effect. Aprepitant may also modestly alter other CYP substrates.
What this interaction means in plain words
Aprepitant and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, which accelerates aprepitant clearance.
What to do
Avoid the combination where possible, and use an alternative antiemetic strategy such as a different class. If given together, monitor for breakthrough emesis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Cobicistat Major
- Aprepitant + Cobimetinib Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Aprepitant with Carbamazepine?
MediHelp rates the interaction as major. Aprepitant and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong CYP3A4 inducer and can markedly reduce aprepitant levels, risking loss of antiemetic effect. Aprepitant may also modestly alter other CYP substrates.
How serious is the interaction between Aprepitant and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and use an alternative antiemetic strategy such as a different class. If given together, monitor for breakthrough emesis.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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