Drug interactions
Aprepitant + Avapritinib
Severity: Major
Aprepitant and Avapritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and avapritinib is a CYP3A4 substrate. Coadministration can raise avapritinib exposure and increase adverse effects such as cognitive effects, intracranial hemorrhage and edema.
What this interaction means in plain words
Aprepitant and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Avapritinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib by aprepitant.
What to do
Avoid the combination where possible, using an alternative antiemetic. If unavoidable, reduce the avapritinib dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
- Aprepitant + Cobimetinib Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Aprepitant with Avapritinib?
MediHelp rates the interaction as major. Aprepitant and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant is a moderate CYP3A4 inhibitor and avapritinib is a CYP3A4 substrate. Coadministration can raise avapritinib exposure and increase adverse effects such as cognitive effects, intracranial hemorrhage and edema.
How serious is the interaction between Aprepitant and Avapritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using an alternative antiemetic. If unavoidable, reduce the avapritinib dose per labeling and monitor for toxicity.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Bosutinib. The full list is on the Aprepitant page.
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