Drug reference
desmopressin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Pituitary Hormones)
Mechanism of action
Synthetic analogue of vasopressin with prompt onset and longer, more specific antidiuretic action; desmopressin increases water permeability in renal tubular cells, which in turn decreases urine volume and increases urine osmolality.
Common side effects
- Dry mouth
- Dizziness
- Headache
- Hyponatremia
Contraindications
- Hypersensitivity Hyponatremia or history of hyponatremia Moderate to severe renal impairment (CrCl <50 mL/min) Intranasal preservative-free (Noctiva) and sublingual tablets: Polydipsia Primary nocturnal enuresis Concomitant use with loop diuretics or systemic or inhaled glucocorti…
Known interactions (2)
Related conditions
Frequently asked questions
What drug class is desmopressin?
desmopressin belongs to: Endocrine.
How does desmopressin work?
Synthetic analogue of vasopressin with prompt onset and longer, more specific antidiuretic action; desmopressin increases water permeability in renal tubular cells, which in turn decreases urine volume and increases urine osmolality.
What are the common side effects of desmopressin?
Dry mouth, Dizziness, Headache, Hyponatremia
Which drugs interact with desmopressin?
ibuprofen, sertraline
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